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Substituted cathinones (also known as cathinones or synthetic cathinones) are a chemical class of psychoactive compounds that are based on the structure of cathinone. The class is composed of all the derivative compounds of cathinone which can be formed by replacing, or substituting, one or more hydrogen atoms in the cathinone core structure with substituents. Examples include MDPV, mephedrone, methylone and a-PVP.
History and possible effects of Cathinones
Cathinone is the active constituent of khat (Catha edullis), a plant whose leaves are chewed on for stimulant effect. Cathinone is closely related in structure to amphetamine, differing solely by a ketone group on the beta carbon.
Structure of Cathinones
Substituted cathinones are a chemical class based upon the molecule cathinone. Cathinones are a sub-category of amphetamines. They share the core amphetamine structure, but are differentiated from substituted amphetamines by a ketone substitution on the beta carbon of the amphetamine structure. Thus, some cathinones, such as βk-MDMA, that differ from a popular substituted amphetamine by the beta ketone substitution, will take the name of the substituted amphetamine, with a "beta-keto"/"βk-" prefix. It should be noted that, although not technically substituted cathinones as they lack the alpha carbon methyl group present in cathinone, there exists a class of psychoactive compounds that differ from various substituted phenethylamines by a beta ketone substitution; most notably βk-2C-B.
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